Changes in mucin 1 expression in a rat model of allergic airway inflammation

ABSTRACT

Purpose: To explore the distribution and expressional changes of mucin 1 (Muc1) in airway of rats with allergic airway inflammation. Materials and Methods: Ovalbumin (OVA) was used to induce acute allergic inflammation in male Wistar rats. The distributions and expressions of Muc1 in lungs of normal and model rats were assessed by immunohistochemical staining and western blotting, respectively. Results: Immunohistochemical staining showed that Muc1 distributed in airway epithelial cells with ciliates, but not those nonciliated cells. Mucin 1 protein expression in the lung was increased during the development of allergic airway inflammation when compared with the normal rats. Conclusion: Mucin 1 distributes in the airway epithelial cells with ciliates and the expressional increase of Muc1 in lung may imply its functions on allergic inflammatory episodes.

KEYWORDS:

• mucin 1
• allergic airway inflammation
• airway epithelial cells
• ovalbumin
• rat

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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Funding

The Thousand of Talents Plan [Granted by the Organization Department of China]