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Original Articles

Calcium (45Ca) uptake inhibition by calcium (Ca2+)‐channel blockers in the presence of two atpase inactivators

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Pages 433-444 | Published online: 21 Nov 2008
 

Abstract

Sorghum [Sorghum bicolor L.I Moench. cv GP‐10, SC574, SC283, and Funk G522DR] root tips (1 cm) were exposed to a concentration series (mM) of calcium (Ca2+) ion channel blockers (i.e. nifedipine, diltiazem, and verapamil) in the presence of p‐chloromercuribenzenesulfonic acid (PCMBS) (1 mM) and ruthenium red (RR) (0.1 mM) at pH 5.5. Calcium (45Ca2+) uptake inhibition by PCMBS and RR were additive. Differences among sorghum cultivars in response to nifedipine, verapamil, and diltiazem showed populations of ion channels whose receptor sites for the ion channel blockers were significantly different. Therefore, populations of ion channels susceptible to different inhibitors must be extant.

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