Vulvar Angiomyxoma, Aggressive Angiomyxoma, and Angiomyofibroblastoma: An Immunohistochemical and Ultrastructural Study

Abstract

To investigate the histogenetical unifying theory of a single, pluripotential primitive cell for vulvar angiomyxoma, aggresive angiomyxoma, and angiomyofibroblastoma, an optical, immunohistochemical and ultrastructural study of a superficial angiomyxoma, aggressive angiomyxoma, and angiomyofibroblastoma was performed. These three tumors showed immunohistochemical and ultrastructural overlapping features. The results of the study suggest that these three tumor entities probably arise on a common pluripotential primitive cell located around the vessels of connective tissue, which could show the capacity for modulating its penotype toward similar but distinct mature cell types.

KEYWORDS:

• aggressive angiomyxoma
• angiomyoblastoma
• angiomyxoma
• myofibroblast
• pericyte
• vulvar tumors