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Ultrastructural Pathology Volume 40, 2016 - Issue 5
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Original Articles: Clinical Research

Aggressive human neuroblastomas show a massive increase in the numbers of autophagic vacuoles and damaged mitochondria

Gordana SamardzijaMother and Child HealthCare Institute of Serbia “Dr Vukan Cupic,” Belgrade, SerbiaView further author information
, MD, MSc,
Tamara Kravic StevovicSchool of Medicine, University of Belgrade, Belgrade, SerbiaView further author information
, MD, PhD,
Slavisa DjuricicMother and Child HealthCare Institute of Serbia “Dr Vukan Cupic,” Belgrade, SerbiaView further author information
, MD, PhD,
Dragomir DjokicMother and Child HealthCare Institute of Serbia “Dr Vukan Cupic,” Belgrade, SerbiaView further author information
, MD, PhD,
Marina DjurisicMother and Child HealthCare Institute of Serbia “Dr Vukan Cupic,” Belgrade, SerbiaView further author information
, BS, PhD,
Darko CiricSchool of Medicine, University of Belgrade, Belgrade, SerbiaView further author information
, MD,
Tamara MartinovicSchool of Medicine, University of Belgrade, Belgrade, SerbiaView further author information
, MD,
Vladimir BumbasirevicSchool of Medicine, University of Belgrade, Belgrade, SerbiaView further author information
, MD, PhD &
Dragana VujicMother and Child HealthCare Institute of Serbia “Dr Vukan Cupic,” Belgrade, Serbia;School of Medicine, University of Belgrade, Belgrade, SerbiaCorrespondence[email protected]
View further author information
, MD, PhD show all
Pages 240-248 | Received 16 Apr 2016, Accepted 05 May 2016, Published online: 16 Aug 2016
 
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ABSTRACT

Autophagy is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance in neuroblastoma (NB). This study was conducted to analyze the ultrastructural features of peripheral neuroblastic tumors (pNTs) and identify the relation of the types of NTs, the proliferation rate, and MYCN gene amplification with a number of autophagic vacuoles. Our results indicate that aggressive human NBs show a massive increase in the number of autophagic vacuoles associated with proliferation rate and that alteration of the mitochondria might be an important factor for the induction of autophagy in NTs.

Acknowledgments

The authors are thankful to Dr. Mileva Micic for her comments and help with the article and to Ljubomir Corovic for the preparation of ultrathin sections.

Funding

The study was supported in part by the Ministry of Education and Science of the Republic of Serbia (grant number 41025).

Additional information

Funding

The study was supported in part by the Ministry of Education and Science of the Republic of Serbia (grant number 41025).

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