Mixed Micellization of Dodecyldimethylamine Oxide with Bile Salts in Aqueous Solutions

Abstract

Micellar behavior of dodecyldimethylamine oxide (DMDAO) with bile salts [sodium deoxycholate (NaDC) and sodium cholate (NaC)] with and without NaCl was studied by surface tension. Interaction parameters of the mixed micelles were estimated using Rubingh's theory. Strong synergism observed for each mixed system, which is a common feature shown by anionic-cationic mixtures. The mixed solutions remained clear even at equimolar ratio. Different behavior of the two bile salts is explained on the basis of their orientation in cationic micelles.

Keywords:

• Bile salts
• interaction parameter
• micellization
• synergism

Acknowledgments

This work was supported by UGC minor research project No.F.32–314/2006 (SR), New Delhi, India.