Colon-Specific Microparticles of Piroxicam: Formulation and Optimization Using 3² Factorial Design

Abstract

The aim of the present study was to prepare and evaluate colon-specific microparticles of piroxicam by oil/water emulsion solvent evaporation method. A 3² factorial design was employed to study the combined influence of two independent variables amount of piroxicam (X₁) and amount of eudragit S-100 (X₂) on dependent variables, encapsulation efficacy (Y₁), percentage cumulative drug release at the fifth hour (Y₂), and percentage cumulative drug release at the tenth hour (Y₃). The microparticles were evaluated for micromeritic properties and drug release studies. Drug–polymer interaction was determined by differential scanning calorimeter, x-ray powder diffraction. The surface morphology and spherocity was studied by scanning electron microscopy. The developed piroxicam microparticles showed desired colon-specific delivery.

Keywords:

• Colon
• eudragit s-100
• factorial design
• microparticles
• piroxicam

Acknowledgments

K. Sanka is thankful to All India Council for Technical Education (New Delhi, India) for providing financial assistance. All of the authors are grateful to Apex Health Care Pvt. Ltd. (Ankleshwar, India) for providing gift sample of Piroxicam. The authors also thank T. Jaypal Reddy, Chairman, St. Peter's Institutions, for providing facilities.

Notes

*Indicates optimized formulation; X1 amount of piroxicam; X2 amount of eudragit S-100; Y1 Encapsulation efficacy; Y2 percentage cumulative drug release at the fifth hour; Y3 percentage cumulative drug release at the tenth hour.

EE encapsulation efficacy; Q5 amount of the drug released at the fifth hour, Q₁₀ amount of the drug released at the tenth hour.