Recrystallization of Microparticles of Fenoprofen Using Rapid Expansion of Supercritical Solution

Abstract

In this study, rapid expansion of supercritical solution with supercritical carbon dioxide as a solvent is used to micronize fenoprofen particles. Effects of different operating parameters were discussed by the method of changing one factor at a time for the extraction temperature (313–333 K), extraction pressure (140–220 bar), collection distance (1–10 cm), nozzle length (2–15 mm), and effective nozzle diameter (450–1700 µm) on the size and morphology of the fenoprofen particles. The conducted experiments revealed that not only the fenoprofen particles were micronized from 24.3 µm to the range of 10.6 µm and 3.3 µm but also the fenoprofen particles experience a modification on their morphologies.

Keywords:

• Fenoprofen
• morphoogy
• recrystallization

Acknowledgments

The authors are grateful to the Shiraz University for supporting this research.

Notes

†The experimental data of run 4.

††The experimental data of run 9.