Use of Formax High-Throughput Platform to Create a Specific Emulsion

Abstract

The Formax high-throughput platform is capable of rapidly mapping out the formulation and process parameters required to produce an array of emulsions with a range of particle sizes. The specific emulsion in this instance is a stable emulsion with a small droplet size, preferably submicron. Using a combination of design of experimental software and high-throughput experimentation, the factors required to produce the emulsion with smallest droplet size were identified. Additionally, this work produced a template which allows the quick and efficient mapping of process and formulation space to determine for new systems which variables have the greatest impact upon the emulsion produced. (Supplemental materials are available for this article. Go to the publisher's online edition of the Journal of Dispersion Science and Technology to view the free supplemental file.)

Keywords:

• D[3,2]
• DoE
• emulsion
• formulation
• high-throughput
• submicron

Acknowledgments

The authors would like to thank the Engineering and Physical Sciences Research Council for Ph.D. funding for D.H.S. Harvey and the Royal Society for the award of a Royal Society Industry Fellowship to A.J. Kowalski. We would like to thank Dr. S. Higgins and Dr. N. Jones of the Centre for Materials Discovery at the University of Liverpool for providing access to the Formax and support throughout this project.