A Comparison Investigation of Coix Seed Oil Liposomes Prepared by Five Different Methods

Chunqing Bai State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, P. R. China

Guowei Luo State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, P. R. China

Yuzhen Liu Jiangxi Vocational and Technical College of Industry and Trade, Nanchang, Jiangxi, P. R. China

Shiqiang Zhao State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, P. R. China

Xuemei Zhu State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, P. R. China

Qiang Zhao State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, P. R. China

Hailong Peng State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, P. R. China; Department of Chemical and Pharmaceutical Engineering, Nanchang University, Nanchang, Jiangxi, P. R. China

Hua Xiong State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, P. R. ChinaCorrespondence[email protected]

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Abstract

The physicochemical properties of coix seed oil (CSO) liposomes prepared by five different methods were evaluated for morphology, encapsulating efficiency, particle size, storage stability, and in vitro release. The different preparation methods resulted in several types of vesicles with different properties. The type of vesicles was closely related to leakage pattern, which affected the storage stability and in vitro release profiles. Ethanol injection method was the best choice for preparing safe and stable liposomes with controlled release. The release mechanisms might account for the diffusion of CSO, and Higuchi was the most suitable model for liposomes stored at high temperature or released in simulated intestinal fluid (SIF).

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A Comparison Investigation of Coix Seed Oil Liposomes Prepared by Five Different Methods

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A Comparison Investigation of Coix Seed Oil Liposomes Prepared by Five Different Methods

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