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Abstract
Pluronics modified liposomes have been prepared and shown to enhance stability of liposomes in our previous reports. In this study, we intended to evaluate the effect of dynamic high pressure microfluidization (DHPM) on the structure and stability of pluronic F127 modified liposomes. The results indicated that the particle size of F127 modified liposomes was decreased from 1180.6 nm to 73.5 nm after DHPM treatment. Meanwhile, the morphology was changed from irregularly multilamellar vesicle to spherically unilamellar structure. Structural characteristics were examined by fourier transformed infrared spectrometer, differential scanning calorimetry and X-ray powder diffraction. The subtle difference of structure might be attributed to the incorporation of PPO chains into the bilayer caused by DHPM treatment. Stability studies indicated that DHPM treatment could enhance the storage and membrane stability of F127 modified liposomes. This study may provide more insight to understand the effect of preparation method on the structure and stability of F127 modified liposomes.
Graphical Abstract
Acknowledgments
We appreciate the financial support by the National Natural Science Foundation of China (No. 21766008 and 21766018), the Youth Fund of Department of Education of Jiangxi Province (No.150804), Major Discipline Academic, Technical Leader Training Plan Project of Jiangxi Province, China (20162BCB22009), Natural Science Foundation of Guangdong Province of China (2017A030307013), Natural Science Foundation of Hainan Province of China (318QN286), Innovation Special Fund Project of Graduate Student of Nanchang University in 2017 (CX2017126).