MULTIPLE EMULSIONS. PART II: PROPOSED TECHNIQUE TO OVERCOME UNPLEASANT TASTE OF DRUGS

Nissim Garti Casali Institute of Applied Chemistry School of Applied Science and Technology The Hebrew University of Jerusalem, Jerusalem, 91904, ISRAEL

Moshe Frenkel Casali Institute of Applied Chemistry School of Applied Science and Technology The Hebrew University of Jerusalem, Jerusalem, 91904, ISRAEL

Rosi Shwartz Casali Institute of Applied Chemistry School of Applied Science and Technology The Hebrew University of Jerusalem, Jerusalem, 91904, ISRAEL

ABSTRACT

Multiple emulsions of water in oil in water (W/O/W) have been used as a novel technique to overcome unpleasant taste of drugs. The drug is dissolved in the inner water phase and is released throughout the oil phase in the presence of synthetic gastric juice

Yield of preparation and stability have been studied using various sets of different inner (emulsifier I) and outer (emulsifier II)emulsifiers

Combination of anionic-nonionic emulsifiers yielded optimal results: High yield of preparation, high stability and complete release of the drug in synthetic gastric juice.

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MULTIPLE EMULSIONS. PART II: PROPOSED TECHNIQUE TO OVERCOME UNPLEASANT TASTE OF DRUGS

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MULTIPLE EMULSIONS. PART II: PROPOSED TECHNIQUE TO OVERCOME UNPLEASANT TASTE OF DRUGS

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