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Abstract
A study of the interaction between a model epidermal lipid and 2(alkoyloxy)-1-[(alkoyloxy)methyl]-ethyl-7-(4 heptyl-5,6-dicarboxyl-2-cyclo-hexene-1-yl)heptanoate, (G2) was made by use of small angle X-ray diffraction. The small angle X-ray diffraction pattern of the epidermal lipid model was first compared to the X-ray pattern obtained from human stratum corneum. Increase in the water content of the model epidermal lipid from 32% to 35% caused a shift in the broad diffraction peak from 50-80Å to 50-70Å. No additional shift was found at further addition of water. The addition of G2 to the 32% water model also caused a shift toward smaller interlayer spacing. The effect of G2 was most dramatic for the model epidermal lipid at the lowest water content.