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Journal of Dispersion Science and Technology Volume 9, 1988 - Issue 4
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Original Articles

ALCOHOL-FREE MICROEMULSIONS

D.W. Osborne Fluids/Ointments R&D The Upjohn Company, Kalamazoo, Michigan, 49001, U.S.A
,
C.A. Middleton Fluids/Ointments R&D The Upjohn Company, Kalamazoo, Michigan, 49001, U.S.A
&
R.L. Rogers Fluids/Ointments R&D The Upjohn Company, Kalamazoo, Michigan, 49001, U.S.A
Pages 415-423 | Published online: 27 Apr 2007
 
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Abstract

Ternary and Pseudo-ternary phase behavior of the system water/hexadecane/dioctyl sodium sulfosuccinate (DSS)/sorbitan laurate has been determined. The microemulsion region of this alcohol-free system has potential for use as a pharmaceutical topical vehicle. A 1/1 weight ratio of sorbitan laurate:DSS (60:40)/hexadecane can solubilize up to 55% water, while sobitan laurate:DSS ratios larger than 70/30 show dramatically decreased water solubilization at equivalent hexadecane concentrations.

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