CHARACTERIZATION OF ION-PAIR FORMATION BETWEEN IONIZED INDOMETHACIN AND CATIONIC SURFACTANTS

ABSTRACT

The interactions between sodium indomethacin and chloride salts of four quaternary ammonium compounds were characterized. Investigations involved conductimetric studies at concentration regions wherein ion-pairs exist in equilibrium with the solution of participating ions. Iontophoresis was also utilized to investigate the phenomenon of ion-pairing. Characteristic of large molecules, extremely high levels of ion-pair association constants and low degrees of dissociation were obtained.

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Notes on contributors

Elizabeth L. Tan

Present Address: Bristol-Myers Squibb Pharmaceutical Research Institute Buffalo, NY 14213

Jue-Chen Liu

Present Address: Johnson & Johnson Technology Resource Center Skillman, NJ 08558