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Original Articles

ASYMMETRY IN LIPOSOME

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Pages 675-683 | Received 22 Dec 1992, Published online: 27 Apr 2007
 

ABSTRACT

Asymmetry of phospholipid distribution along the vertical axis of the bimoiecular membrane in a liposome prepared with soybean phospholipids, PC and PE, was studied by using on ESR technique. From the difference in the values of the order parameter of doxylstearic acid radicals between the sample solutions into which the radicals were added before and after preparation of the liposome, it was concluded that PE is incorporated only in the inner layer of the liposome in the range of 0-30% of PE in mixed PC/PE systems and PE is incorporated in both layers of the liposome over about 30% of PE in the mixture.

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