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Abstract
The kinetics and distribution of platelet deposition on protein‐coated surfaces were studied in an in vitro flow system. When fluorescence‐labeled platelets in whole blood flow through a flow chamber that is composed of a glass plate, platelets will deposit onto the protein‐coated surface in a time‐and location‐dependent manner. A combination of fluorescence video microscopy and a digital image processing system allowed us to systematically study thrombosis kinetics under various flow conditions, with different biomaterials and forms of blood.
In this paper, the image processing and pattern recognition techniques have been developed to quantify adhered platelets from numerous video frames. The dynamic adhesion status (newly attached, staying, detached) has been calculated automatically by software developed on an IBM/PC/386. These morphometric parameters as a function of flow rate and type of biomaterials can be determined experimentally.
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Correspondence addressee