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Abstract
Coenzyme F430 is a Ni(II)-containing corphinoid which was first isolated from the cells of methanogenic archaebacteria in 1978. The cofactor F430 is responsible for the conversion of CO2 into CH4 in the methanogenic process. Starting from the first structural studies of coenzyme F430 with application of NMR and biosynthetic methods, many papers have been published to discuss the structural features as well as the biocatalytic role of F430. However, a precise understanding of the mechanism of F430-dependent catalysis is lacking. With a focus on what is known about the F430-dependent biocatalysis in methanogens, the results of physical and chemical studies of F430 are presented. In addition. functions of novel enzymes involved in the methanogenic process are discussed.