X-Ray Structural Studies of Metal-Nucleoside and Metal-Nucleoside Monophosphate Complexes: New Perspectives

Abstract

The X-ray structures of metal-nucleoside and metal-nucleoside monophosphate complexes published from 1980 to the end of 1991 are examined and classified. The first 3d trans bis divalent metal ion-nucleoside complex and the first thymidine complexes with Au and Hg are discussed. The structures for purine nucleotides are classified as [M(NMP)(H₂O)₅]; cis-[M(NMP)₂]; ternary M(NMP)(L), where L is a pyridine such as dpa, phen, or bpy, of three subtypes: (a) no direct M-NMP bonding and intramolecular stacking between the nucleotide and the base, (b) with a M–O(phosphate) bond and (c) with a M–N(7) of the purine base bond; and polymeric. The more relevant metal-pyrimidine nucleotide structures are also discussed.

Key Words:

• metal ion
• nucleoside
• nucleotide
• X-ray structure