Context–dependent interactions of left posterior inferior frontal gyrus in a local visual search task unrelated to language

Abstract

The Embedded Figures Task (EFT) involves search for a target hidden in a complex geometric pattern. Even though the EFT is designed to probe local visual search functions, not language–related processes, neuropsychological studies have demonstrated a strong association between aphasia and impairment on this task. A potential explanation for this relationship was offered by a recent functional MRI study (Manjaly et al., 2003), which demonstrated that a part of the left posterior inferior frontal gyrus (pIFG), overlapping with Broca's region, is crucially involved in the execution of the EFT. This result suggested that pIFG, an area strongly associated with language–related functions, is also part of a network subserving cognitive functions unrelated to language. In this study, we tested this conjecture by analysing the data of Manjaly et al. for context–dependent functional interactions of the pIFG during execution of the EFT. The results showed that during EFT, compared to a similar visual matching task with minimal local search components, pIFG changed its interactions with areas commonly involved in visuospatial processing: Increased contributions to neural activity in left posterior parietal cortex, cerebellar vermis, and extrastriate areas bilaterally, as well as decreased contributions to bilateral temporo–parietal cortex, posterior cingulate cortex, and left dorsal premotor cortex were found. These findings demonstrate that left pIFG can be involved in nonlanguage processes. More generally, however, they provide a concrete example of the notion that there is no general one–to–one mapping between cognitive functions and the activations of individual areas. Instead, it is the spatiotemporal pattern of functional interactions between areas that is linked to a particular cognitive context.

Acknowledgments

JCM and JMG are supported by the Medical Research Council (MRC), UK. KZ and GRF are supported by the Deutsche Forschungsgemeinschaft (DFG–KFO 112), Germany. KES is funded by the Wellcome Trust, UK. Additional support from the VolkswagenStiftung to JCM, KZ, and GRF is gratefully acknowledged.