Effects of the characteristics of chitosan on controlling drug release of chitosan coated PLLA microspheres

Abstract

Chitosan has been shown to be a biomaterial with good biocompatibility, and is highly biodegradable. This study investigated the effect of post-coating PLLA microspheres with different chitosans on the initial burst and controlling the drug release of the microspheres. Without chitosan, 19.2% of encapsulated lidocaine would release from PLLA microspheres within the first hour (R₁), and the time of 50% release (T₅₀

Keywords::

• Chitosan Plla Microsphere Controlled Drug Release