Long-acting delivery microspheres of levo-norgestrolpoly(3-hydroxybutyrate): their preparation, characterization and contraceptive tests on mice

Abstract

The preparative technology for sustained release drug delivery microspheres of levo-norgestrol-poly(3-hydroxybutyrate) was optimized based on the in-liquiddrying method. The formation of the drug microspheres was confirmed with differential thermal analysis. The appearance, particle size and distribution, residual CHCl₃, drug content, drug release characteristics in vitro

Keywords::

• Levo-NORGESTROL Poly(3-HYDROXYBUTYRATE) Sustained Release Drug Delivery Microspheres Contraceptive