Nifedipine encapsulated core-shell type nanoparticles based on poly(γ-benzyl L-glutamate)/poly(ethylene glycol) diblock copolymers

Y.-I. Jeong The Research Institute of Medical Science, Chonnam National University, 5, Hak-1-dong, Dong-Gu, Gwangju 501-746, KoreaCorrespondence[email protected]

H.-S. Sun The Research Institute of Medical Science, Chonnam National University, 5, Hak-1-dong, Dong-Gu, Gwangju 501-746, Korea

Y.-H. Shim Hankook Bio Pharm. R&D, Seoul 158-072, Korea; Structure et Fonction Molecules Bioactive, Universite Pierre et Marie Curie, Paris Cedex 05, France

C. Kim Applied Chemical Engineering, Chonnam National University, Gwangju 500-757, Korea

S.-H. Park Applied Chemical Engineering, Chonnam National University, Gwangju 500-757, Korea

K.-C. Choi The Research Institute of Medical Science, Chonnam National University, 5, Hak-1-dong, Dong-Gu, Gwangju 501-746, Korea

C.-S. Cho School of Biological Resources & Materials Engineering, Seoul National University, Seoul 441-744, Korea

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Abstract

The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was slower in longer PBLG chain length and higher NFD contents than short PBLG chain length and lower drug contents of NFD due to the hydrophobic interaction between PBLG domain and NFD.

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Nifedipine encapsulated core-shell type nanoparticles based on poly(γ-benzyl L-glutamate)/poly(ethylene glycol) diblock copolymers

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Nifedipine encapsulated core-shell type nanoparticles based on poly(γ-benzyl L-glutamate)/poly(ethylene glycol) diblock copolymers

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