Emulsification preparation of chitosan–urethane microbeads in the presence of a water-soluble blocked diisocyanate, containing furanone homosyrine lactone bacterial inhibitors

R. R. Price Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC, USA

L. C. Passaro Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC, USA

E. R. Welsh United States Naval Academy, Chemistry Department, Annapolis, MD, USA

Abstract

Chitosan is an abundant naturally occurring biopolymer that is biocompatible, of low toxicity and is well suited as a carrier for a range of active agents. Restrictions imposed by this biopolymers unique solubility requirements make if difficult to process. One approach to an internal setting system is to employ the water-soluble blocked isocyanate hexamethylene-1,6-di(aminocarboxysulphonate) (HDACS) in order to cross-link the chitosan and form microspheres in situ utilizing simple emulsion systems. Chitothane microspheres are capable of delivering active agents at controlled release rates and offers a viable alternative to external set methodologies utilizing aldehydes or similar cross-linking agents.

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Emulsification preparation of chitosan–urethane microbeads in the presence of a water-soluble blocked diisocyanate, containing furanone homosyrine lactone bacterial inhibitors

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Emulsification preparation of chitosan–urethane microbeads in the presence of a water-soluble blocked diisocyanate, containing furanone homosyrine lactone bacterial inhibitors

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