Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

Hwa Young Park Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea

Keun Sang Oh Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea

Hyoung Mo Koo Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea

Sun Hang Cho Nanobiomaterials Laboratories, Yusung, Daejeon, Korea

Sang Jun Chung BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusung, Daejeon, Korea

Yong Taik Lim BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusung, Daejeon, Korea

Dongmin Kim School of Electrical, Electronic and Computer Engineering, Hongik University, Jochiwon, Chungnam, Korea

Soon Hong Yuk Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea

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Abstract

Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).

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Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

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Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

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