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Abstract
Objective: To develop and evaluate solidified-reverse-micellar-solution (SRMS)-based oromucosal nano lipid gels for improved localised delivery of miconazole nitrate (MN).
Methods: Phospholipon® 90G and Softisan® 154 (3:7) were used to prepare SRMS by fusion. Solid lipid nanoparticles (SLNs, 0.25–1.0% w/w MN) formulated with the SRMS by high shear homogenisation were employed to prepare mucoadhesive nano lipid gels. Physicochemical characterisation, drug release in simulated salivary fluid (SSF) (pH 6.8) and anti-candidal activity were carried out.
Results: The SLNs were spherical nanoparticles, had mean size of 133.8 ± 6.4 to 393.2 ± 14.5 nm, low polydispersity indices, good encapsulation efficiency (EE) (51.96 ± 2.33–67.12 ± 1.65%) and drug loading (DL) (19.05 ± 2.44–24.93 ± 1.98%). The nano lipid gels were stable, spreadable, pseudoplastic viscoelastic mucoadhesive systems that exhibited better prolonged release and anti-candidal properties than marketed formulation (Daktarin® oral gel) (p < 0.05).
Conclusion: This study has shown that SRMS-based nano lipid gels could be employed to prolong localised oromucosal delivery of MN.
Acknowledgements
This work makes part of the doctoral activities of Franklin Chimaobi Kenechukwu. We thank Phospholipid GmbH, Köln, Germany for providing Phospholipon® 90 G (P90G) used in this study. We also acknowledge Lubrizol Corporation, Ohio, United States of America for the kind gift of Noveon® (Polycarbophil). We also wish to thank the Institut für Pharmazeutische Technologie, Technische Universität Carolo-Wilhelmina zu Braunschweig, Braunschweig, Germany for the use of HAAKE ThermoRheoWin rheometer in their laboratory for the rheological study.
Disclosure statement
The authors report no conflict of interest concerning the work.