172
Views
21
CrossRef citations to date
0
Altmetric
Research Article

Novel solidified reverse micellar solution-based mucoadhesive nano lipid gels encapsulating miconazole nitrate-loaded nanoparticles for improved treatment of oropharyngeal candidiasis

, &
Pages 592-609 | Received 31 May 2017, Accepted 17 Aug 2017, Published online: 06 Sep 2017
 

Abstract

Objective: To develop and evaluate solidified-reverse-micellar-solution (SRMS)-based oromucosal nano lipid gels for improved localised delivery of miconazole nitrate (MN).

Methods: Phospholipon® 90G and Softisan® 154 (3:7) were used to prepare SRMS by fusion. Solid lipid nanoparticles (SLNs, 0.25–1.0% w/w MN) formulated with the SRMS by high shear homogenisation were employed to prepare mucoadhesive nano lipid gels. Physicochemical characterisation, drug release in simulated salivary fluid (SSF) (pH 6.8) and anti-candidal activity were carried out.

Results: The SLNs were spherical nanoparticles, had mean size of 133.8 ± 6.4 to 393.2 ± 14.5 nm, low polydispersity indices, good encapsulation efficiency (EE) (51.96 ± 2.33–67.12 ± 1.65%) and drug loading (DL) (19.05 ± 2.44–24.93 ± 1.98%). The nano lipid gels were stable, spreadable, pseudoplastic viscoelastic mucoadhesive systems that exhibited better prolonged release and anti-candidal properties than marketed formulation (Daktarin® oral gel) (p < 0.05).

Conclusion: This study has shown that SRMS-based nano lipid gels could be employed to prolong localised oromucosal delivery of MN.

Acknowledgements

This work makes part of the doctoral activities of Franklin Chimaobi Kenechukwu. We thank Phospholipid GmbH, Köln, Germany for providing Phospholipon® 90 G (P90G) used in this study. We also acknowledge Lubrizol Corporation, Ohio, United States of America for the kind gift of Noveon® (Polycarbophil). We also wish to thank the Institut für Pharmazeutische Technologie, Technische Universität Carolo-Wilhelmina zu Braunschweig, Braunschweig, Germany for the use of HAAKE ThermoRheoWin rheometer in their laboratory for the rheological study.

Disclosure statement

The authors report no conflict of interest concerning the work.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.