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Abstract
Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement, encapsulation efficiency, drug loading and in vitro drug release. Mass yield was between 5.5 and 45.9%. The particle size was between 15.1 and 26.8 µm. Encapsulation efficiency were 96.142 ± 5.931 and 85.571 ± 3.301; drug loading were 65.261 ± 3.914% and 37.844 ± 4.339% of L2 and N1, respectively. Well-separated, mainly spherical microparticles with suitable properties were obtained. Optimum microparticles were applied to tampons. Physical properties and visual characteristics of tampons were investigated before and after binder application. In vitro drug release from tampons were also examined. According to the results, textile-based carrier systems loaded microparticles containing nifedipine and lidocaine HCl will be an effective and promising alternative for current anal fissure treatment.
Acknowledgements
This study was supported by a research grant from Dokuz Eylül University (2014.KB.FEN.045). The authors would like to thank Res. Assist. Akar DOĞAN, Mechanical Engineering, Dokuz Eylul University for enabling to use compressibility tester. The authors would also like to acknowledge Ege University Pharmaceutical Sciences Research Center (FABAL) for enabling to use its laboratory instruments (UPLC).
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.