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ORIGINAL ARTICLES

Development and characterization of morin hydrate-loaded micellar nanocarriers for the effective management of Alzheimer’s disease

, , , , , & show all
Pages 137-148 | Received 07 Oct 2017, Accepted 14 Feb 2018, Published online: 01 Mar 2018
 

Abstract

The aim of this study was to prepare and characterise oral delivery of morin hydrate-loaded micellar nanocarriers using Pluronic P127 and Pluronic F123 for the effective management of Alzheimer’s disease. After administration of formulation brain and blood drug concentration were found to be highest for optimised morin hydrate-loaded micellar nanocarriers as compared to plain morin hydrate. Significant (p < 0.05) reduction in assessed pharmacodynamic parameters was observed after administration of morin hydrate-loaded micellar nanocarriers as compared to disease control group. Chronic treatment with morin-loaded micelles significantly increased the memory in AlCl3 induced Alzheimer’s disease in Wistar rats.

Disclosure statement

No potential conflict of interest was reported by the authors.

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