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Abstract
Context: Flavonoids show promising anticancer potential but it is limited due to poor solubility. Objective: The present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluated for potential increase in the anti-cancer activity against MCF-7 cell line. Methods: The physiochemical characteristics and release kinetics for Ch-SLNs and Ch-PC-SLNs were evaluated and compared. Storage stability of Ch-PC-SLNs was evaluated up to 3 months. Solid state properties (DSC, XRD) and morphology (AFM) of Ch-PC-SLNs were also studied. In-vitro anticancer activity was investigated by using MTT assay. Results and Discussion: Ch-PC-SLNs exhibited higher encapsulation efficiency than Ch-SLNs and zero order release kinetics. Ch-PC-SLNs were found to be stable upto 3 months upon lyophilisation with mannitol as cryoprotectant. DSC and XRD study revealed the loss of highly crystalline nature of Chrysin in Ch-PC-SLNs. The Ch-PC-SLNs lead to significantly higher in-vitro anticancer activity than that of bulk Chrysin. Conclusion: The study concludes that phospholipids complex with Chrysin lead to improve encapsulation, storage stability of SLNs and in vitro anticancer activity.
Acknowledgements
The authors gratefully acknowledge the Director, CSIR-CDRI, Lucknow for providing required facilities. Authors are also thankful to Dr. P.R Mishra, Division of Pharmaceutics, CSIR CDRI, Lucknow for using the AFM facility. Authors also acknowledge the SAIF, Panjab University Chandigarh to perform SEM and X-Ray Diffraction studies of the samples.
Disclosure statement
The authors declare that they have no conflicts of interest.