pH-responsive glucosamine anchored polydopamine coated mesoporous silica nanoparticles for delivery of Anderson-type polyoxomolybdate in breast cancer

Abstract

Aim

This study aimed to develop novel pH-sensitive Glucosamine (Glu) targeted Polydopamine (PDA) coated mesoporous silica (SBA-15) nanoparticles (NPs) for selective delivery of anticancer Anderson-type manganese polyoxomolybdate (POMo) to breast cancer.

Methods

The POMo@SBA-PDA-Glu NPs were prepared via direct hydrothermal synthesis of SBA, POMo loading, in situ PDA post functionalization, and Glu anchoring; the chemical structures were fully studied by different characterisation methods. The anticancer activity was studied by MTT method and Annexin V-FITC apoptosis detection kit.

Results

The optimised NPs had a hydrodynamic size (HS) of 195 nm, a zeta potential (ZP) of −18.9 mV, a loading content percent (LC%) of 45%, and a pH-responsive release profile. The targeted NPs showed increased anticancer activity against breast cancer cell lines compared to the free POMo with the highest cellular uptake and apoptosis level in the MDA-MB-231 cells.

Conclusions

POMo@SBA-PDA-Glu NPs could be a promising anticancer candidate for further studies.

Keywords:

• Anderson-type manganese polyoxomolybdate (POMo)
• barbara amorphous-15 mesoporous Silica (SBA-15)
• polydopamine (PDA)
• anticancer activity
• nanoparticles (NPs)
• targeted drug delivery

Acknowledgement

We acknowledge the financial support of Novel Drug Delivery Systems Research Center at Isfahan University of Medical Sciences, Grant Number: 298036. Furthermore, we acknowledge Dr. Khadijeh Ramezani-Aliakbari and Dr. Saeid Asghari for their compassionate advice during this research.

Declaration of competing interest

The authors report no conflicts of interest.

Additional information

Funding

The financial support of Novel Drug Delivery Systems Research Center at Isfahan University of Medical Sciences, Grant Number: 298036.