Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation

Abstract

It has previously been demonstrated that hyperthermia can activate prostaglandin synthesis and that prostaglandins are protective against hyperthermia. This study examined the use of inhibitors of prostaglandin synthesis on the response of prostate tumours to hyperthermia. The non-steroidal anti-inflammatory drugs (NSAID) ibuprofen and sulindac, known cyclooxygenase inhibitors that inhibit prostaglandin production, were effective hyperthermia sensitizers and augmented growth delay of DU-145 and PC-3 prostate tumours to combined radiation and hyperthermia treatment protocols. Pre-treatment of mice with ibuprofen and sulindac at hyperthermia sensitizing doses resulted in significant ( p < 0.01) inhibition of hyperthemia-induced serum prostaglandin E 2 . These findings indicate that NSAID may have both sensitizing effects on prostate tumour growth and may function by inhibiting prostaglandin synthesis.

• Cyclooxygenase Hyperthermia Prostate Cancer Non-STEROIDAL Anti-INFLAMMATORY Drugs Radiation Thermotolerance