Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity

M. Kuang The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

S. Q. Liu Johns Hopkins University, Baltimore, MD, USA

K. Saijo RIKEN (The Institute of Physical and Chemical Research), Ibaraki, Japan

E. Uchimura RIKEN (The Institute of Physical and Chemical Research), Ibaraki, Japan; Tsukuba-Lab, Ibaraki, Japan

L. Huang RIKEN (The Institute of Physical and Chemical Research), Ibaraki, Japan

K.W. Leong Johns Hopkins University, Baltimore, MD, USA

M. D. Lu The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

J. F. Huang The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

T. Ohno RIKEN (The Institute of Physical and Chemical Research), Ibaraki, Japan; Tsukuba-Lab, Ibaraki, JapanCorrespondence[email protected]

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Abstract

After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use.

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Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity

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Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity

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