Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques

Abstract

The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.

• Hyperthermia
• liposome
• imaging
• MRI
• PET
• chemodosimetry
• dose painting
• drug delivery
• nanoparticle

Notes

Notes

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