A Bayesian inference of P(λ₁<λ₂) for two Poisson parameters

Abstract

The statistical inference drawn from the difference between two independent Poisson parameters is often discussed in the medical literature. However, such discussions are usually based on the frequentist viewpoint rather than the Bayesian viewpoint. Here, we propose an index θ=P(λ_{1, post}<λ_{2, post}), where λ_{1, post} and λ_{2, post} denote Poisson parameters following posterior density. We provide an exact and an approximate expression for calculating θ using the conjugate gamma prior and compare the probabilities obtained using the approximate and the exact expressions. Moreover, we also show a relation between θ and the p-value. We also highlight the significance of θ by applying it to the result of actual clinical trials. Our findings suggest that θ may provide useful information in a clinical trial.

Keywords:

• gamma distribution
• hypergeometric series
• Poisson distribution
• posterior distribution
• $p$-value