A generalized Q–Q plot for longitudinal data

Abstract

Most biomedical research is carried out using longitudinal studies. The method of generalized estimating equations (GEEs) introduced by Liang and Zeger [Longitudinal data analysis using generalized linear models, Biometrika 73 (1986), pp. 13–22] and Zeger and Liang [Longitudinal data analysis for discrete and continuous outcomes, Biometrics 42 (1986), pp. 121–130] has become a standard method for analyzing non-normal longitudinal data. Since then, a large variety of GEEs have been proposed. However, the model diagnostic problem has not been explored intensively. Oh et al. [Modeldiagnostic plots for repeated measures data using the generalized estimating equations approach, Comput. Statist. Data Anal. 53 (2008), pp. 222–232] proposed residual plots based on the quantile–quantile (Q–Q) plots of the χ²-distribution for repeated-measures data using the GEE methodology. They considered the Pearson, Anscombe and deviance residuals. In this work, we propose to extend this graphical diagnostic using a generalized residual. A simulation study is presented as well as two examples illustrating the proposed generalized Q–Q plots.

Keywords:

• longitudinal data
• generalized estimating equations
• generalized residual
• Q–Q plot

Acknowledgements

This work was partially supported by grants GR42/10-962004 and MTM2009-06997. The authors gratefully acknowledge two anonymous referees for their constructive comments and suggestions, which led to great improvements in the manuscript.