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Abstract
Many research fields increasingly involve analyzing data of a complex structure. Models investigating the dependence of a response on a predictor have moved beyond the ordinary scalar-on-vector regression. We propose a regression model for a scalar response and a surface (or a bivariate function) predictor. The predictor has a random component and the regression model falls in the framework of linear random effects models. We estimate the model parameters via maximizing the log-likelihood with the ECME (Expectation/Conditional Maximization Either) algorithm. We use the approach to analyze a data set where the response is the neuroticism score and the predictor is the resting-state brain function image. In the simulations we tried, the approach has better performance than two other approaches, a functional principal component regression approach and a smooth scalar-on-image regression approach.
Acknowledgements
The authors would like to thank Professor Goldsmith for the help in implementing the approach in [Citation16]. The authors also want to thank the 1000 Functional Connectomes Project and the International Neuroimaging Data-sharing Initiative for sharing the data (http://fcon_1000.projects.nitrc.org/).
Disclosure statement
No potential conflict of interest was reported by the authors.
