Non-parametric estimation with doubly censored data

Data from longitudinal studies in which an initiating event and a subsequent event occur in sequence are called 'doubly censored' data if the time of both events is interval-censored. This paper is concerned with using doubly censored data to estimate the distribution function of the so-called 'duration time', i.e. the elapsed time between the originating event and the subsequent event. The paper proposes a generalization of the Gomez and Lagakos two-step method for the case where both the time to the initiating event and the duration time are continuous. This approach is applied to estimate the AIDS-latency time from a haemophiliacs cohort.