Surface engineered bimetallic nanoparticles based therapeutic and imaging platform: recent advancements and future perspective

Abstract

The unique physical and chemical properties of monometallic nanoparticles have been comprehensively explored. Analogously, the combination of two metals induces alterations in the system’s electron density, termed as Bimetallic nanoparticles (BMNP’s) were found to be more desirable than monometallic nanoparticles due to improved stability, activity, and selectivity, thus altering the chemical, optical, and electrical properties. In this review, we showcase the importance in the context of biomedical applications. The article sheds light on utilising BMNP’s in the field of theranostics, diagnosis, and therapeutics by focusing on anticancer, antimicrobial and wound healing activity along with the toxicological problems associated with BMNP’s. In conclusion, BMNP’s can be used as a novel therapeutic and diagnostic system to tackle major health concerns.

GRAPHICAL ABSTRACT

KEYWORDS:

• Bimetallic nanoparticles
• sputtering
• thermal decomposition
• toxicity
• safety

Acknowledgements

The authors are thankful to (i) Manipal Academy of Higher Education (MAHE), Manipal, India (for Postdoctoral Fellowship) to Dr Abhijeet Pandey and Dr TMA Pai Doctoral Fellowship to Gasper Fernandes, Ajinkya N Nikam and Sanjay Kulkarni. The authors are also thankful to Manipal College of Pharmaceutical Sciences, MAHE, Manipal, India for providing necessary facilities. Authors are also thankful to Biorender.com, a figure making tool.

Disclosure statement

No potential conflict of interest was reported by the author(s).