Abstract
New chiral dopants were synthesised from naproxen and hexyloxyphenol or benzyloxyphenol, and their helical twisting power (HTP) and helical senses determined. Their HTP values were largely influenced by the position of the substituents and the type of linkage between the chiral centre and the core part. Ester‐linked chiral dopants with 1,4‐substitution of the benzene ring showed relatively large HTP values. However, ether‐linked chiral dopants with 1,2‐substitution showed larger molar HTP values than those with 1,4‐substitution.
Acknowledgement
The present study was supported by a Grant‐in‐Aid for Scientific Research (No. 16750154) from the Ministry of Education, Culture, Sports, Science and Technology.