A review of self-organising 2,5- and 2,4-disubstituted 1,3-thiazole-containing materials: synthesis, mechanisms and tactics

ABSTRACT

2,5- and 2,4-disubstituted 1,3-thiazoles have been incorporated as core units in thermotropic liquid crystalline materials. However, synthetic approaches to these systems have been somewhat limited, and this is reflected in the relatively few reports of these mesogenic systems. This paper highlights both recent and well-established synthetic approaches to these systems using ring closure (Gabriel- and Hantzsch-type approaches) methodology and modifications of an intact 1,3-thiazole ring. The scope and limitations of each of these approaches are discussed.

Graphical Abstract

KEYWORDS:

• 1, 3-Thiazole
• liquid crystals
• synthesis
• Lawesson’s reagent

Acknowledgements

We would like to thank all of the current and former graduate and undergraduate students in our research group who have worked on the synthesis of liquid crystalline 1,3-thiazoles; this includes Alan Grubb, Andrey Kiryanov, Pritha Subramanian, Larissa Nassif, Sean Carney and Tiffany Koval.

Disclosure statement

No potential conflict of interest was reported by the authors.