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Original Article

Isolation and analysis of ketoconazole resistant mutants of Saccharomyces cerevisiae

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Pages 153-162 | Accepted 23 Mar 1988, Published online: 09 Jul 2009
 

Abstract

Nine mutants of Saccharomyces cerevisiae which are resistant to ketoconazole, have been isolated and characterized. In each case the mutation is nuclear in origin and allelic to a previously described mutation, erg3, which gives rise to a block in the Δ5–6 desaturation step of ergosterol biosynthesis. The significance of this second site mutation to the point of inhibitory action of ketoconazole, that is the P-450-mediated C-14 demethylation of lanosterol, is discussed.

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