Interstrain variation in the deoxynucleotide composition of Cryptococcus neoformans: nucleotide composition of Cryptococcus neoformans

D. Podwall Albert Einstein College of Medicine, Bronx, New York, USA

E. Yador Albert Einstein College of Medicine, Bronx, New York, USA

S. Miller Albert Einstein College of Medicine, Bronx, New York, USA

J. Pena Albert Einstein College of Medicine, Bronx, New York, USA

S.P. Franzot Albert Einstein College of Medicine, Bronx, New York, USA

J. Lipetz Albert Einstein College of Medicine, Bronx, New York, USA

A. Casadevall Albert Einstein College of Medicine, Bronx, New York, USA

J.J. Steinberg Albert Einstein College of Medicine, Bronx, New York, USA

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Abstract

The deoxynucleotide (dNMP) composition of ten strains of C. neoformans was analysed by ³²P-labelling and two-dimensional thin-layer chromatography. This technique is very sensitive for detecting rare deoxynucleotide adducts and analogues (minor bases) in DNA. The results indicate considerable variation among strains in DNA nucleotide composition.

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Interstrain variation in the deoxynucleotide composition of Cryptococcus neoformans: nucleotide composition of Cryptococcus neoformans

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Interstrain variation in the deoxynucleotide composition of Cryptococcus neoformans: nucleotide composition of Cryptococcus neoformans

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