Interfered-Naming Therapy for Aphasia (INTA): a neuroscience-based approach to improve linguistic-executive processing

ABSTRACT

Background and Aims

Research just started to combine behavioural, computational, and neural accounts to investigate the nature of post-stroke aphasia, but the dynamic aspect of aphasia recovery has rarely been integrated. Moreover, executive functions in aphasia recently gained attention as an important contributor to language performance. Lexical picture/word interference embraces both executive control and language processing through distracted confrontation naming, as revealed by functional magnetic resonance imaging. Thus, we for the first time applied this complex paradigm in diagnostic and therapeutic settings for persons with aphasia (PWA) on the group level. In consideration of behavioural and computational data, we aimed at investigating the neural responses of persons with aphasia (a) to a novel treatment method targeting both word processing and language control by means of interfered-naming, and (b) to the interfering stimuli to determine preserved and impaired processing and changes thereof.

Methods and Procedures

Nineteen PWA at a mean age of 51 years (range 21–74) and 26 months post-onset (4–63) as well as 22 matched healthy controls were included in a diagnostic fMRI study comprising a pure naming test and the lexical fMRI interference paradigm with five distractor conditions (phonological, associative-semantic, categorical-semantic, unrelated word, unrelated noise) in a 3 T Philips scanner. Twelve participants completed the 4-weeks therapy, 11 the fMRI therapy study. During therapy, both comprehension of the interfering words and distracted but cued picture naming were trained.

Outcomes and Results

The distribution of lexical-semantic and -phonological impairments of PWA in the computational model was well balanced. The novel linguistic-executive treatment significantly improved pure and interfered naming for the PWA group, fostering generalisation to untrained items, reducing repetition of distractors, and ameliorating lexical-semantic processing. The predicted behavioural effects of distractor types were only found for the two semantic conditions. Neuroimaging revealed right-hemisphere compensation before treatment, activation decrease related to enhanced efficiency due to treatment, and both differential and overlapping responses to distractor types. Key brain regions encompassed inferior frontal gyrus and right posterior middle temporal gyrus as well as the basal temporal language area, cerebellum, and anterior cingulate cortex.

Conclusions

The novel interfered-naming in aphasia therapy revealed to be effective, but differential effects of distractor types were less prominent than expected. Behavioural, computational, and neural findings converge on identifying semantic-executive processing as the core source of improvements. This account of linguistic-executive processing in aphasia offers a step towards a comprehensive theory of neurorehabilitation.

KEYWORDS:

• Aphasia
• treatment
• neuroimaging
• fMRI
• interference

Acknowledgments

We thank student assistants Inga Hameister, Veronika Loescher, Elisabeth Meyer, and Stephanie Koehler for deliverance of speech therapy and routine assistance; the Brain Imaging Core Facility, Interdisciplinary Centre for Clinical Research (IZKF) at Aachen University Hospital; and all participants for their participation. We also thank the Reviewers for their thoughtful and helpful comments.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Supplementary material

Supplemental data for this article can be accessed here.

Additional information

Funding

This research was supported by the German Research Foundation (DFG, AB 282/2-1; Own Position).