Atypical teratoid/rhabdoid tumor in adult: case series and an integrated survival analysis

Abstract

Background

Atypical teratoid/rhabdoid tumor (AT/RT) is well documented in children but less so in adults because of its rarity.

Method

We report a series of five cases, a literature review and quantitative analysis of the survival outcome of adult AT/RT patients.

Results

Seventy-four patients including our five cases (male: female = 16: 58) were evaluated, whose median age was 32.5 years (18–80 years). The commonest location was the sellar region. Median overall survival (OS) was 12.5 months (0.5–204.00 months). Chemotherapy was associated with OS (HR: 0.349, 95%CI: 0.176–0.694, p = 0.003), while other factors did not influence OS. From Kaplan-Meier analysis, surgery combining postoperative chemotherapy and radiotherapy was associated with better prognosis (Log Rank: χ² = 14.662, p = 0.001).

Conclusions

Adult AT/RT is commoner in females and tends to recur rapidly after surgical resection. Chemotherapy may provide a survival benefit. Surgery combined with postoperative chemotherapy and radiotherapy was associated with better prognosis for adult AT/RT patients, though the overall prognosis was still poor.

Keywords:

• Atypical teratoid/rhabdoid tumor
• chemotherapy
• radiotherapy
• surgery
• quantitative analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).