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Brain Injury Volume 31, 2017 - Issue 9: Veterans Affairs Traumatic Brain Injury Conference: State of the Art
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Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Ibolja CernakMilitary and Veterans’ Clinical Rehabilitation Research, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, CanadaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3214-698X
ORCID Icon,
Donald G. SteinEmory School of Medicine, Department of Emergency Medicine Brain Research Laboratory, Atlanta, Georgia, USA
,
Gregory A. ElderJames J. Peters VA Medical Center, Bronx, NY, USA;Icahn School of Medicine at Mount Sinai, New York, New York, USA
,
Stephn AhlersOperational and Undersea Medicine, Naval Medical Research Center, Silver Spring, MD, USA
,
Kenneth CurleyIatrikos Research and Development Strategies, LLC, Tampa, FL, USA;Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
,
Ralph G. DePalmaVA ORD & Department of Surgery, Uniformed Services University of the Health Sciences, Office of Research and Development, Washington, DC, USA
,
John DudaParkinson’s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center; and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
,
Milos IkonomovicDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
,
Grant L. IversonNeuropsychology Outcome Assessment Laboratory, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA
,
Firas KobeissyPsychoproteomics and Nanotechnology Research Center, Department of Psychiatry, The Evelyn F and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA
,
Vassilis E. KoliatsosDepartment of Pathology (Neuropathology) and Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
,
Michael J. Leggieri Jr.DoD Blast Injury Research Program Coordinating Office, U.S. Army Medical Research and Materiel Command, Ft Detrick, MD, USA
,
Anthony M. PacificoAlzheimer’s and Epilepsy Research Programs, Congressionally Directed Medical Research Programs; US Department of Health and Human Services, Telemedicine and Advanced Technology Research Center, Fort Detrick, MD, USA
,
Douglas H. SmithThe Robert A. Groff Professor of Neurosurgery/Research and Education, Department of Neurosurgery/PENN’s Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, PA, USA
,
Raymond SwansonDepartment of Neurology, University of California San Francisco; and Neurology Service, SFVAMC, San Francisco, CA, USA
,
Floyd J. ThompsonBrain Rehabilitation Research Center, Malcom Randall VAMC; Physiological Sciences and Professor Emeritus, Neuroscience, University of Florida, Gainesville, FL, USA
&
Frank C. TortellaBranch of Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research; Silver Spring, MD, USA
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Pages 1168-1176 | Received 17 Jul 2016, Accepted 23 Nov 2016, Published online: 05 Oct 2017
 
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ABSTRACT

As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls.

Declaration of Interest

The authors report no declarations of interest.

Disclaimer

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any institution, organization or government agency.

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