Modulation of working memory load distinguishes individuals with and without balance impairments following mild traumatic brain injury

ABSTRACT

Objectives: Balance and gait deficits can persist after mild traumatic brain injury (TBI), yet an understanding of the underlying neural mechanism remains limited. The purpose of this study was to investigate differences in attention network modulation in patients with and without balance impairments 2–8 weeks following mild TBI.

Methods: Using functional magnetic resonance imaging, we compared activity and functional connectivity of cognitive brain regions of the default mode, central-executive and salience networks during a 2-back working memory task in participants with mild TBI and balance impairments (n = 7, age 47 ± 15 years) or no balance impairments (n = 7, age 47 ± 15 years).

Results: We first identified greater activation in the lateral occipital cortex in the balance impaired group. Second, we observed stronger connectivity of left pre-supplementary motor cortex in the balance impaired group during the working memory task, which was related to decreased activation of regions within the salience and central executive networks and greater suppression of the default mode network.

Conclusions: Results suggest a link between impaired balance and modulation of cognitive resources in patients in mTBI. Findings also highlight the potential importance of moving beyond traditional balance assessments towards an integrative assessment of cognition and balance in this population.

KEYWORDS:

• Attention
• balance
• cognition
• functional connectivity
• traumatic brain injury

Funding

This research was supported by the Department of Defense award #W81XWH-08-1-0725 and #W81XWH-12-1-0098.

Additional information

Funding

This research was supported by the Department of Defense award #W81XWH-08-1-0725 and #W81XWH-12-1-0098.