183
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Admission circulating monocytes level is an independent predictor of outcome in traumatic brain injury

, , , , , & show all
Pages 515-522 | Received 09 Apr 2017, Accepted 14 Jan 2018, Published online: 22 Jan 2018
 

ABSTRACT

Objective: The aim of this study was to assess the prognostic value of admission immune cell levels in the peripheral blood in determining outcomes in patients with TBI.

Method: We studied 141 adult patients with mild-to-severe TBI (Glasgow Coma Scale (GCS) 3–15). Patient outcome was assessed using the Extended Glasgow Outcome Scale (GOSE) at 6 months post-injury. The area under the curve (AUC) was used to evaluate the predictive ability of immune cell levels. Uni- and multivariate analyses were performed to assess the independent predictors of 6-month outcome.

Results: We found that admission monocyte count was not only a better predictor (AUC = 0.778; 95% confidence interval (CI), 0.679–0.858) of favourable outcomes (GOSE 5–8) at 6 months post-injury than were admission haemoglobin (AUC = 0.629; 95% CI, 0.522–0.728) and blood glucose (AUC = 0.616; 95% CI, 0.508–0.716) levels for patients with moderate-to-severe TBI (GCS ≤ 12), but also an independent predictor of 6-month outcome (adjusted odds ratio, 1.35; 95% CI, 1.10–1.65; p = 0.004).

Conclusions: The present study suggests that an increase in admission monocyte count is correlated with a favourable 6-month outcome in patients with moderate-to-severe TBI.

Disclosure Statement

No competing financial interests exist.

Conflicts of Interest

The authors declare that they have no competing financial interests.

Additional information

Funding

This study was supported by National Natural Science Foundation of China (NSFC) [grant number 81271375].

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.