![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Purpose: To determine whether a sphincter-like control point is present in 90° branches of the retinal vasculature. Such a control point could selectively control retinal blood flow to the deeper capillary layers. Methods: A microperfusion system was used in which porcine retinal arteries with intact branches were cannulated and perfused intraluminally at physiological flow rates. The vasoactive response of the proximal and distal regions of either 90°-or Y-type branches to intraluminal potassium (124 mM) were monitored simultaneously in real-time. Results: The proximal region of the 90° branches demonstrated a localized vasoconstriction when compared to the more distal region (p < 0.0001). In contrast, the Y branches contracted evenly along their length. Conclusions: The localized vasoactivity near the branch point of the 90°-type branches may explain previous observations of so-called sphincter-like activity in these vessels. These sphincters may selectively regulate blood flow to the deeper retinal capillary layer.