Dorzolamide/Timolol Fixed Combination Versus Latanoprost/Timolol Fixed Combination in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension

Abstract

Purpose: The efficacy of dorzolamide/timolol fixed combination (DTFC) versus latanoprost/timolol fixed combination (LTFC) in open-angle glaucoma or ocular hypertensive patients. Methods: Patients were randomized to DTFC or LTFC for 6 weeks and switched to opposite treatment for Period 2. Results: Thirty-two completed patients had a mean diurnal IOP of 19.5 ± 3.2 mmHg for DTFC and 18.9 ± 3.4 mmHg for LTFC (p = 0.12), with no significant difference found between DTFC and LTFC at any timepoint following a Bonferroni correction (p ≥ 0.01). Conclusions: Patients treated with DTFC and LTFC have a statistically similar ocular hypotensive effect.

KEYWORDS:

• dorzolamide/timolol fixed combination
• latanoprost/timolol fixed combination
• timolol gel forming solution