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Current Eye Research Volume 45, 2020 - Issue 2
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Glaucoma

Optic Nerve Traction During Adduction in Open Angle Glaucoma with Normal versus Elevated Intraocular Pressure

Joseph L. DemerDepartment of Ophthalmology, University of California, Los Angeles, CA, USA;Stein Eye Institute, University of California, Los Angeles, CA, USA;Biomedical Engineering Interdepartmental Program, University of California, Los Angeles, CA, USA;Neuroscience Interdepartmental Program, University of California, Los Angeles, CA, USA;Department of Neurology, University of California, Los Angeles, CA, USACorrespondence[email protected]
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Robert A. ClarkDepartment of Ophthalmology, University of California, Los Angeles, CA, USA;Stein Eye Institute, University of California, Los Angeles, CA, USAORCID Iconhttps://orcid.org/0000-0002-2422-0337View further author information
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Soh Youn SuhDepartment of Ophthalmology, University of California, Los Angeles, CA, USAView further author information
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Joann A. GiaconiDepartment of Ophthalmology, University of California, Los Angeles, CA, USA;Stein Eye Institute, University of California, Los Angeles, CA, USAView further author information
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Kouros Nouri-MahdaviDepartment of Ophthalmology, University of California, Los Angeles, CA, USA;Stein Eye Institute, University of California, Los Angeles, CA, USAView further author information
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Simon K. LawDepartment of Ophthalmology, University of California, Los Angeles, CA, USA;Stein Eye Institute, University of California, Los Angeles, CA, USAView further author information
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Laura BonelliDepartment of Ophthalmology, University of California, Los Angeles, CA, USA;Stein Eye Institute, University of California, Los Angeles, CA, USAView further author information
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Anne L. ColemanDepartment of Ophthalmology, University of California, Los Angeles, CA, USA;Stein Eye Institute, University of California, Los Angeles, CA, USAView further author information
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Joseph CaprioliDepartment of Ophthalmology, University of California, Los Angeles, CA, USA;Stein Eye Institute, University of California, Los Angeles, CA, USAView further author information
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Pages 199-210 | Received 22 Jul 2019, Accepted 21 Aug 2019, Published online: 02 Dec 2019
 
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ABSTRACT

Purpose/Aim: We used magnetic resonance imaging (MRI) to investigate effects of intraocular pressure (IOP), race, and other factors on optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in open angle glaucoma (OAG).

Materials and Methods: Thirty-five patients with OAG (26 with maximal untreated IOP ≤21 mmHg, 9 with IOP >21mmHg) and 48 controls underwent axial and quasi-coronal MRI in central gaze and large (27–33°) abduction and adduction. Some underwent MRI at smaller ductions (21–28°). Effects of presence vs. absence of OAG; within OAG whether maximum IOP level was ≤21 mmHg vs. >21 mmHg; adduction angle; race; age; and gender on ON path length and globe translation were analyzed using generalized estimating equations to account for possible intereye correlations of individual subjects.

Results: Average visual field mean deviation (±standard error of mean, SEM) was −8.2 ± 1.2 dB in OAG with normal IOP, and −6.1 ± 1.4 in high IOP. In central gaze, ON path in OAG was significantly more redundant than in controls but in both groups the ON became significantly and almost equally straighter in small (~21°) or large (~27°) adduction than in central gaze. With progressive adduction only, globes retracted in OAG (P < 0.005) but not in controls; this was only weakly related to globe size and not to IOP elevation. Globe retraction in adduction was significant only in OAG, and in that group was significantly greater in Asian than white patients (P < 0.02).

Conclusions: Although ON tethering in adduction is normal, progressive adduction is associated with abnormal globe retraction in OAG regardless of IOP level. This phenomenon is more prominent in Asians who have OAG. Traction in adduction may cause repetitive strain injury to the ON and peripapillary sclera, thus contributing to the optic neuropathy of glaucoma independent of IOP.

Disclosure Statement

None of the authors has a financial interest in any material related to this paper.

Additional information

Funding

This work was supported by U.S. Public Health Service, National Eye Institute under grants EY008313 and EY000331; and by Research to Prevent Blindness under an Unrestricted Grant to the Department of Ophthalmology. J. Demer is the Arthur L. Rosenbaum Professor of Pediatric Ophthalmology.

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