Evaluation of Ocular Parameters in Adult Patients with Celiac Disease

ABSTRACT

Purpose

To evaluate ophthalmic parameters in adult celiac patients

Methods

This cross-sectional study included 31 celiac patients (58 eyes) and 25 healthy controls (50 eyes). Tear break up time (TBUT), schirmer test were measured; corneal thickness, anterior chamber parameters were obtained using scheimpflug camera; retinal nerve fiber layer thickness (RNFL) evaluated by using spectral domain optical cohorence tomography.

Results

There were no statistically significant differences between the groups in terms of gender, age, and intraocular pressure (p > .05). Schirmer’s test results and TBUT were significantly lower in celiac patients (p < .001, p < .001). Additionally, the superior RNFL was significantly thinner (p = .017), nasal RNFL thicker (p = .007), and anterior chamber depth larger (p = .037) in celiac patients. The tissue transglutaminase 2 IgA antibody and superior RNFL were negatively correlated (r = −0.394, p = .012). The anterior chamber volume and anti-gliadin IgA antibody were positively correlated (r = 0.369 p = .027).

Conclusion

Celiac disease affects Schirmer’s test results, TBUT, segmental RNFL thickness, and anterior chamber parameters. Ocular parameters might be affected in celiac disease especially in the presence of high antibody titer.

KEYWORDS:

• Celiac disease
• antibody
• retinal nerve fiber layer
• anterior chamber

Disclosure statement

The authors have no conflicts of interest.